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Article

Estrogen receptor α polymorphisms and the risk of cognitive decline: A 2-year follow-up study.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 May 2014

Ma Suk Ling, Tang Nelson Leung Sang, Leung Grace Tak Yu, Fung Ada Wai Tung, Lam Linda Chiu Wa

Abstract excerpt

OBJECTIVE: The neuroprotective role of estrogen is supported by biochemical studies, but the results from clinical trials of estrogen replacement therapy on cognitive decline are controversial. One possible missing link might be the interindividual difference in estrogen receptor expression. In this study, the association of estrogen receptor α (ESR1) polymorphisms and cognitive decline was investigated. METHODS:...

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Source

Identifiers

PMID: 23567436
DOI: 10.1016/j.jagp.2012.08.006

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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