Article
Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study.
Neurobiology of aging - 1 Apr 2009
Yaffe Kristine, Lindquist Karla, Sen Saunak, Cauley Jane, Ferrell Robert, Penninx Brenda, Harris Tamara, Li Rongling, Cummings Steven R
Abstract excerpt
OBJECTIVE: To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women. BACKGROUND: Several single nucleotide polymorphisms (SNPs) on ESR1 and ESR2 genes have been associated with a range of hormone sensitive diseases such as breast cancer and osteoporosis. Genetic variations in ESR may also...
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