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Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations.

Dementia and geriatric cognitive disorders - 1 Jan 2006

Corbo Rosa Maria, Gambina Giuseppe, Ruggeri Maria, Scacchi Renato

Abstract excerpt

BACKGROUND: Many studies have shown that estrogen replacement therapy may improve cognitive function in women and reduce the risk of Alzheimer's disease (AD). Because most of the estrogen neuroprotective effect is mediated by receptors, we studied the associations between estrogen receptor alpha (ESR1) polymorphisms (PvuII and XbaI) and AD, and their interactions with apolipoprotein E (APOE) polymorphism and...

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Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
DNA
Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropsychological Tests

Reverse Transcriptase Polymerase Chain Reaction

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Identifiers

PMID: 16699281
DOI: 10.1159/000093315

Genes

ESR1
APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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