Article
Progression from amnesic mild cognitive impairment to Alzheimer's disease: ESR1 and ESR2 polymorphisms and APOE gene.
Dementia and geriatric cognitive disorders - 1 Jan 2011
Elcoroaristizabal Martín X, Fernández Martínez M, Galdos Alcelay L, Molano Salazar A, Bereincua Gandarias R, Inglés Borda S, Gómez Busto F, Uterga Valiente J M, Indakoetxea Juanbeltz B, Gómez Beldarraín M A, de Pancorbo M M
Abstract excerpt
BACKGROUND: Many genes have been studied to determine how they might be involved in Alzheimer's disease (AD). Estrogens have a protective effect in the central nervous system. The mechanisms of action of estrogens are mediated by two estrogen receptors (ERs), ERα and ERβ. Thus, these genes could also play a role in the progression of amnesic mild cognitive impairment (MCIa) to AD. The aim of this study was to...
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