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Article

The Distinct Roles of NEIL1 and XPA in Limiting Aflatoxin B1-Induced Mutagenesis in Mice.

Molecular cancer research : MCR - 2 Jan 2025

Luzadder Michael M, Minko Irina G, Vartanian Vladimir L, Davenport Marten, Fedorov Lev M, McCullough Amanda K, Lloyd R Stephen

Abstract excerpt

Dietary exposure to aflatoxin B1 (AFB1) is a risk factor for the development of hepatocellular carcinomas. Following metabolic activation, AFB1 reacts with guanines to form covalent DNA adducts, which induce high-frequency G > T transversions. The molecular signature associated with these mutational events aligns with the single-base substitution signature 24 (SBS24) in the Catalog of Somatic Mutations in Cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39387543
DOI: 10.1158/1541-7786.MCR-24-0577
PMCID: PMC11695181

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