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Article

Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct.

Carcinogenesis - 1 Jul 2014

Lin Ying-Chih, Li Liang, Makarova Alena V, Burgers Peter M, Stone Michael P, Lloyd R Stephen

Abstract excerpt

Aflatoxin B1 (AFB1) is a known carcinogen associated with early-onset hepatocellular carcinoma (HCC) and is thought to contribute to over half a million new HCCs per year. Although some of the fundamental risk factors are established, the molecular basis of AFB1-induced mutagenesis in primate cells has not been rigorously investigated. To gain insights into genome instability that is produced as a result of...

Topics

Aflatoxin B1
Animals
COS Cells
Carcinoma, Hepatocellular
Chlorocebus aethiops
DNA Adducts
DNA Replication
DNA, Single-Stranded
Humans
Liver Neoplasms
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Pyrimidines

Source

Open in PubMed Open full text

Identifiers

PMID: 24398669
DOI: 10.1093/carcin/bgu003
PMCID: PMC4076807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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