Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct.

Carcinogenesis - 1 Jul 2014

Lin Ying-Chih, Li Liang, Makarova Alena V, Burgers Peter M, Stone Michael P, Lloyd R Stephen

Abstract excerpt

Aflatoxin B1 (AFB1) is a known carcinogen associated with early-onset hepatocellular carcinoma (HCC) and is thought to contribute to over half a million new HCCs per year. Although some of the fundamental risk factors are established, the molecular basis of AFB1-induced mutagenesis in primate cells has not been rigorously investigated. To gain insights into genome instability that is produced as a result of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aflatoxin B1
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to COS Cells

Share to DNA Adducts

Share to DNA Replication

Share to DNA, Single-Stranded

Share to Pyrimidines

Source

Open in PubMed Open full text

Identifiers

PMID: 24398669
DOI: 10.1093/carcin/bgu003
PMCID: PMC4076807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct.PMID 24398669Read ↗

Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.Semantic proximity Read ↗

In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.Semantic proximity Read ↗

Genome-scale mutational signatures of aflatoxin in cells, mice and human tumorsSemantic proximity Read ↗

Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors.Semantic proximity Read ↗

The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis.Semantic proximity Read ↗

Structurally Similar Mycotoxins Aflatoxin B1 and Sterigmatocystin Trigger Different and Distinctive High-Resolution Mutational Spectra in Mammalian Cells.Semantic proximity Read ↗

An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.Semantic proximity Read ↗

Mutational analysis of the C8-guanine adduct of the environmental carcinogen 3-nitrobenzanthrone in human cells: critical roles of DNA polymerases η and κ and Rev1 in error-prone translesion synthesis.Semantic proximity Read ↗

Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.Semantic proximity Read ↗

The Distinct Roles of NEIL1 and XPA in Limiting Aflatoxin B1-Induced Mutagenesis in Mice.Semantic proximity Read ↗

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.Semantic proximity Read ↗

Structure and mechanism of error-free replication past the major benzo[a]pyrene adduct by human DNA polymerase κSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.