Article
Long-term load duration induces N-cadherin down-regulation and loss of cell phenotype of nucleus pulposus cells in a disc bioreactor culture.
Bioscience reports - 30 Apr 2017
Li Pei, Zhang Ruijie, Wang Liyuan, Gan Yibo, Xu Yuan, Song Lei, Luo Lei, Zhao Chen, Zhang Chengmin, Ouyang Bin, Tu Bing, Zhou Qiang
Abstract excerpt
Long-term exposure to a mechanical load causes degenerative changes in the disc nucleus pulposus (NP) tissue. A previous study demonstrated that N-cadherin (N-CDH)-mediated signalling can preserve the NP cell phenotype. However, N-CDH expression and the resulting phenotype alteration in NP cells under mechanical compression remain unclear. The present study investigated the effects of the compressive duration on...
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