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Article

A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 2014

Hirata Hiroaki, Yurube Takashi, Kakutani Kenichiro, Maeno Koichiro, Takada Toru, Yamamoto Junya, Kurakawa Takuto, Akisue Toshihiro, Kuroda Ryosuke, Kurosaka Masahiro, Nishida Kotaro

Abstract excerpt

The intervertebral disc nucleus pulposus (NP) has two phenotypically distinct cell types-notochordal cells (NCs) and non-notochordal chondrocyte-like cells. In human discs, NCs are lost during adolescence, which is also when discs begin to show degenerative signs. However, little evidence exists regarding the link between NC disappearance and the pathogenesis of disc degeneration. To clarify this, a rat tail disc...

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PMID: 24285589
DOI: 10.1002/jor.22533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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