Article
N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions.
Scientific reports - 13 Jun 2016
Hwang Priscilla Y, Jing Liufang, Chen Jun, Lim Foon-Lian, Tang Ruhang, Choi Hyowon, Cheung Kenneth M, Risbud Makarand V, Gersbach Charles A, Guilak Farshid, Leung Victor Y, Setton Lori A
Abstract excerpt
Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extracellular matrix that contributes to disc health and mechanical function. NP cells have a unique morphology and molecular expression pattern derived from their notochordal origin, and reside in N-cadherin (CDH2) positive cell clusters in vivo. With disc degeneration, NP cells undergo morphologic and phenotypic changes...
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