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Article

Dynamic Compression Promotes the Matrix Synthesis of Nucleus Pulposus Cells Through Up-Regulating N-CDH Expression in a Perfusion Bioreactor Culture.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2018

Xu Yichun, Yao Hui, Li Pei, Xu Wenbin, Zhang Junbin, Lv Lulu, Teng Haijun, Guo Zhiliang, Zhao Huiqing, Hou Gang

Abstract excerpt

BACKGROUND/AIMS: An adequate matrix production of nucleus pulposus (NP) cells is an important tissue engineering-based strategy to regenerate degenerative discs. Here, we mainly aimed to investigate the effects and mechanism of mechanical compression (i.e., static compression vs. dynamic compression) on the matrix synthesis of three-dimensional (3D) cultured NP cells in vitro. METHODS: Rat NP cells seeded on...

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PMID: 29614512
DOI: 10.1159/000488616

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FOXF1
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