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Article

Comparative analysis in continuous expansion of bovine and human primary nucleus pulposus cells for tissue repair applications.

European cells & materials - 24 Mar 2017

Rosenzweig D H, Tremblay Gravel J, Bisson D, Ouellet J A, Weber M H, Haglund L

Abstract excerpt

Autologous NP cell implantation is a potential therapeutic avenue for intervertebral disc (IVD) degeneration. However, monolayer expansion of cells isolated from surgical samples may negatively impact matrix production by way of dedifferentiation. Previously, we have used a continuous expansion culture system to successfully preserve a chondrocyte phenotype. In this work, we hypothesised that continuous expansion...

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Source

Identifiers

PMID: 28345732
DOI: 10.22203/eCM.v033a18

Genes

CHAD
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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