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Article

Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development.

Arthritis research & therapy - 1 Jan 2013

Purmessur Devina, Guterl Clare C, Cho Samuel K, Cornejo Marisa C, Lam Ying W, Ballif Bryan A, Laudier James C Iatridis, Iatridis James C

Abstract excerpt

INTRODUCTION: Notochordal cells (NCs) pattern aneural and avascular intervertebral discs (IVDs), and their disappearance, is associated with onset of IVD degeneration. This study induced and characterized the maturation of nucleus pulposus (NP) tissue from a gelatinous NC-rich structure to a matrix-rich structure populated by small NP cells using dynamic pressurization in an ex vivo culture model, and also...

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Identifiers

PMID: 24427812
DOI: 10.1186/ar4302
PMCID: PMC3978427

Genes

SHH
IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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