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Article

Environmental regulation of notochordal gene expression in nucleus pulposus cells.

Journal of cellular physiology - 1 Sept 2009

Rastogi Anshu, Thakore Pratiksha, Leung Aileen, Benavides Magda, Machado Monica, Morschauser Michael A, Hsieh Adam H

Abstract excerpt

Cells of the nucleus pulposus (NP) in the intervertebral disc are derived directly from the embryonic notochord. In humans, a shift in NP cell population coincides with the beginning of age-related changes in the extracellular matrix that can lead to spinal disorders. To begin identifying the bases of these changes, the manner by which relevant environmental factors impact cell function must be understood. This...

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PMID: 19472213
DOI: 10.1002/jcp.21816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Environmental regulation of notochordal gene expression in nucleus pulposus cells.PMID 19472213Read ↗

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