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Article

Loss of notochordal cell phenotype in 3D-cell cultures: implications for disc physiology and disc repair.

Archives of orthopaedic and trauma surgery - 1 Dec 2014

Omlor G W, Nerlich A G, Tirlapur U K, Urban J P, Guehring T

Abstract excerpt

INTRODUCTION: Embryonic notochordal disc nucleus cells (NC) have been identified to protect disc tissue against disc degeneration but in human beings NC phenotype gets lost with aging and the pathophysiological mechanisms are poorly understood. NC may stimulate other cells via soluble factors, and NC-conditioned medium can be used to stimulate matrix production of other disc cells and mesenchymal stem cells and...

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Identifiers

PMID: 25348151
DOI: 10.1007/s00402-014-2097-2

Genes

CLC
KRT8

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