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Article

Use of whole-genome sequencing to distinguish relapse from reinfection in a completed tuberculosis clinical trial.

BMC medicine - 29 Mar 2017

Witney Adam A, Bateson Anna L E, Jindani Amina, Phillips Patrick P J, Coleman David, Stoker Neil G, Butcher Philip D, McHugh Timothy D

Abstract excerpt

BACKGROUND: RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole-genome sequencing (WGS) is evaluated within RIFAQUIN for identifying new infections in treated patients as either relapses or reinfections. WGS is further compared with mycobacterial interspersed repetitive units-variable number tandem...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28351427
DOI: 10.1186/s12916-017-0834-4
PMCID: PMC5371199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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