Article
Recurrence due to relapse or reinfection with Mycobacterium tuberculosis: a whole-genome sequencing approach in a large, population-based cohort with a high HIV infection prevalence and active follow-up.
The Journal of infectious diseases - 1 Apr 2015
Guerra-Assunção José Afonso, Houben Rein M G J, Crampin Amelia C, Mzembe Themba, Mallard Kim, Coll Francesc, Khan Palwasha, Banda Louis, Chiwaya Arthur, Pereira Rui P A, McNerney Ruth, Harris David, Parkhill Julian, Clark Taane G, Glynn Judith R
Abstract excerpt
BACKGROUND: Recurrent tuberculosis is a major health burden and may be due to relapse with the original strain or reinfection with a new strain. METHODS: In a population-based study in northern Malawi, patients with tuberculosis diagnosed from 1996 to 2010 were actively followed after the end of treatment. Whole-genome sequencing with approximately 100-fold coverage was performed on all available cultures....
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