Article
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study.
The Lancet. Respiratory medicine - 1 Dec 2013
Bryant Josephine M, Harris Simon R, Parkhill Julian, Dawson Rodney, Diacon Andreas H, van Helden Paul, Pym Alex, Mahayiddin Aziah A, Chuchottaworn Charoen, Sanne Ian M, Louw Cheryl, Boeree Martin J, Hoelscher Michael, McHugh Timothy D, Bateson Anna L C, Hunt Robert D, Mwaigwisya Solomon, Wright Laura, Gillespie Stephen H, Bentley Stephen D
Abstract excerpt
BACKGROUND: Recurrence of tuberculosis after treatment makes management difficult and is a key factor for determining treatment efficacy. Two processes can cause recurrence: relapse of the primary infection or re-infection with an exogenous strain. Although re-infection can and does occur, its importance to tuberculosis epidemiology and its biological basis is still debated. We used whole-genome sequencing-which...
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