Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy cases

15 Jun 2017

Abstract excerpt

BACKGROUND: Since leprosy is both treated and controlled by multidrug therapy (MDT) it is important to monitor recurrent cases for drug resistance and to distinguish between relapse and reinfection as a means of assessing therapeutic efficacy. All three objectives can be reached with single nucleotide resolution using next generation sequencing and bioinformatics analysis of Mycobacterium leprae DNA present in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leprosy Research and Treatment
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28617800
DOI: 10.1371/journal.pntd.0005598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequencing distinguishes between relapse and reinfection in recurrent leprosy casesPMID 28617800Read ↗

Recurrence due to relapse or reinfection with Mycobacterium tuberculosis: a whole-genome sequencing approach in a large, population-based cohort with a high HIV infection prevalence and active follow-up.Semantic proximity Read ↗

Distinguishing Relapse From Reinfection With Whole-Genome Sequencing in Recurrent Pulmonary Tuberculosis: A Retrospective Cohort Study in Beijing, ChinaSemantic proximity Read ↗

Whole genome analysis of Mycobacterium tuberculosis isolates from recurrent episodes of tuberculosis, Finland, 1995-2013.Semantic proximity Read ↗

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study.Semantic proximity Read ↗

Distinguishing Relapse from Reinfection in Recurrent Tuberculosis: A Genomic and Epidemiologic Study in BrazilSemantic proximity Read ↗

Genotyping of Mycobacterium leprae from Brazilian leprosy patients suggests the occurrence of reinfection or of bacterial population shift during disease relapse.Semantic proximity Read ↗

Human Genetic Susceptibility of Leprosy Recurrence.Semantic proximity Read ↗

Genotypic investigation of Mycobacterium leprae in patients with relapsing leprosy in Mato Grosso, Brazil.Semantic proximity Read ↗

Recurrence of tuberculosis in a low-incidence setting: a retrospective cross-sectional study augmented by whole genome sequencing.Semantic proximity Read ↗

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.Semantic proximity Read ↗

Endogenous relapse and exogenous reinfection in recurrent pulmonary tuberculosis: A retrospective study revealed by whole genome sequencingSemantic proximity Read ↗

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium lepraeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.