Article
A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.
BMC infectious diseases - 7 Jan 2020
Wollenberg Kurt, Harris Michael, Gabrielian Andrei, Ciobanu Nelly, Chesov Dumitru, Long Alyssa, Taaffe Jessica, Hurt Darrell, Rosenthal Alex, Tartakovsky Michael, Crudu Valeriu
Abstract excerpt
BACKGROUND: Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs through relapse of the initial infection or reinfection by a new drug-resistant strain. Outbreaks of DR-TB in high burden regions present unique challenges in determining recurrence status for effective disease management and treatment. In the Republic of Moldova the burden of DR-TB is exceptionally high, with many cases...
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