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Article

Whole Genome Sequence Analysis of a Large Isoniazid-Resistant Tuberculosis Outbreak in London: A Retrospective Observational Study.

PLoS medicine - 1 Oct 2016

Casali Nicola, Broda Agnieszka, Harris Simon R, Parkhill Julian, Brown Timothy, Drobniewski Francis

Abstract excerpt

BACKGROUND: A large isoniazid-resistant tuberculosis outbreak centred on London, United Kingdom, has been ongoing since 1995. The aim of this study was to investigate the power and value of whole genome sequencing (WGS) to resolve the transmission network compared to current molecular strain typing approaches, including analysis of intra-host diversity within a specimen, across body sites, and over time, with...

Topics

Adult
Child
DNA, Bacterial
Disease Outbreaks
Genome, Bacterial
Humans
Isoniazid
London
Minisatellite Repeats
Mycobacterium tuberculosis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retrospective Studies

Sequence Analysis, DNA

Tuberculosis

Tuberculosis, Pulmonary

Source

Open in PubMed Open full text

Identifiers

PMID: 27701423
DOI: 10.1371/journal.pmed.1002137
PMCID: PMC5049847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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