Article

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.

2019-12-23

Abstract excerpt

<title>Abstract</title> <p>Background Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs through relapse of the initial infection or reinfection by a new drug-resistant strain. Outbreaks of DR-TB in high burden regions present unique challenges in determining recurrence status for effective disease management and treatment. In the Republic of Moldova the burden of DR-TB is exceptionally high...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cf4afcd2-2e90-5a8d-b566-0f91806e006d
DOI: 10.21203/rs.2.14414/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.DOI 10.21203/rs.2.14414/v3Read

Mixed-strain infection and heteroresistance in drug-resistant tuberculosis: insights from a whole-genome sequencing pilotSemantic proximity Read

Distinguishing Relapse from Reinfection in Recurrent Tuberculosis: A Genomic and Epidemiologic Study in BrazilSemantic proximity Read

Recurrence due to relapse or reinfection with Mycobacterium tuberculosis: a whole-genome sequencing approach in a large, population-based cohort with a high HIV infection prevalence and active follow-up.Semantic proximity Read

The global phylogeography of rapidly expanding multidrug resistant Ural lineage 4.2 Mycobacterium tuberculosis.Semantic proximity Read

Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis.Semantic proximity Read

QuantTB – A method to classify mixed <i>Mycobacterium tuberculosis</i> infections within whole genome sequencing dataSemantic proximity Read

Genomic insights into extrapulmonary tuberculosis reveal enrichment of lineage 2 with high drug resistance in specific clinical phenotypesSemantic proximity Read

Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil.Semantic proximity Read

Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study.Semantic proximity Read

Relapse, re-infection and mixed infections in tuberculosis diseaseSemantic proximity Read

Genomic markers of drug resistance in Mycobacterium tuberculosis populations with minority variants.Semantic proximity Read