Article
The fitness costs and benefits of antibiotic resistance in drug-free microenvironments encountered in the human body.
Environmental microbiology reports - 1 Oct 2017
Maharjan Ram, Ferenci Thomas
Abstract excerpt
The relationship between bacterial drug resistance and growth fitness is a contentious topic, but some antibiotic resistance mutations clearly have a fitness cost in the laboratory. Whether these costs translate into deleterious effects in natural habitats is less certain however. Previously, fitness effects of resistance mutations were mostly characterized in nutrient-rich, fast-growth conditions, which bacteria...
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