Article
Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.
Experimental neurology - 1 Jun 2017
Rosenblum Lauren Taylor, Shamamandri-Markandaiah Shashirekha, Ghosh Biswarup, Foran Emily, Lepore Angelo C, Pasinelli Piera, Trotti Davide
Abstract excerpt
Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in its c-terminus domain, a proteolytic cleavage that also occurs in vivo in the mutant SOD1 mouse...
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