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Article

BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.

JCI insight - 23 Aug 2018

Wang Zhi-Hao, Wu Wanqiang, Kang Seong Su, Liu Xia, Wu Zhiping, Peng Junmin, Yu Shan Ping, Manfredsson Fredric P, Sandoval Ivette M, Liu Xuebo, Wang Jian-Zhi, Ye Keqiang

Abstract excerpt

AEP is an age-dependent lysosomal asparaginyl endopeptidase that cleaves numerous substrates including tau and α-synuclein and mediates their pathological roles in neurodegenerative diseases. However, the molecular mechanism regulating this critical protease remains incompletely understood. Here, we show that Akt phosphorylates AEP on residue T322 upon brain-derived neurotrophic factor (BDNF) treatment and...

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Identifiers

PMID: 30135302
DOI: 10.1172/jci.insight.99007
PMCID: PMC6141178

Genes

BDNF
SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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