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Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls

24 Oct 2000

Abstract excerpt

OBJECTIVE: To ascertain the specificity of alternatively spliced mRNA variants of the astroglial glutamate transporter EAAT2 for ALS. BACKGROUND: An important hypothesis for ALS pathogenesis is that motor neuron injury may result from chronically elevated glutamate levels in the CNS. Supporting this idea are reports of decreased glutamate transport in ALS. This in turn has recently been suggested to be due to the...

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PMID: 11071482
DOI: 10.1212/wnl.55.8.1082

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