Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related Neurodegeneration

21 May 2024

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder. While there are five FDA-approved drugs for treating this disease, each has only modest benefits. To design new and more effective therapies for ALS, particularly for sporadic ALS of unknown and diverse etiologies, we must identify key, convergent mechanisms of disease pathogenesis. This review focuses on the origin and effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Genetic Neurodegenerative Diseases
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38891774
DOI: 10.3390/ijms25115587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Revisiting Glutamate Excitotoxicity in Amyotrophic Lateral Sclerosis and Age-Related NeurodegenerationPMID 38891774Read ↗

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an updateSemantic proximity Read ↗

Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Novel therapeutic targets for amyotrophic lateral sclerosis.Semantic proximity Read ↗

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosisSemantic proximity Read ↗

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseasesSemantic proximity Read ↗

Mechanisms of neurodegeneration in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Excitotoxicity in ALS: Overstimulation, or overreaction?Semantic proximity Read ↗

Role of excitotoxicity in the degeneration of motor neurones in ALSSemantic proximity Read ↗

Molecular and Cellular Mechanisms Affected in ALSSemantic proximity Read ↗

Early pathogenesis in the adult-onset neurodegenerative disease amyotrophic lateral sclerosis.Semantic proximity Read ↗

Amyotrophic lateral sclerosis is a multifactorial disease.Semantic proximity Read ↗

ALS: a disease of motor neurons and their nonneuronal neighbors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.