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Article

A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis.

Molecular neurobiology - 1 Mar 2020

Maurel Cindy, Chami Anna A, Thépault Rose-Anne, Marouillat Sylviane, Blasco Hélène, Corcia Philippe, Andres Christian R, Vourc'h Patrick

Abstract excerpt

In amyotrophic lateral sclerosis, motor neurons undergoing degeneration are characterized by the presence of cytoplasmic aggregates containing TDP-43 protein. SUMOylation, a posttranslational modification of proteins, has been previously implicated in the formation of aggregates positives for SOD1, another protein enriched in a subset of ALS patients. We show in this study that TDP-43 is also a target of...

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PMID: 31728929
DOI: 10.1007/s12035-019-01810-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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