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Article

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1.

Neurochemistry international - 1 Dec 2008

Sheldon Amanda L, González Marco I, Krizman-Genda Elizabeth N, Susarla Bala T S, Robinson Michael B

Abstract excerpt

Sodium-dependent glutamate uptake is essential for limiting excitotoxicity, and dysregulation of this process has been implicated in a wide array of neurological disorders. The majority of forebrain glutamate uptake is mediated by the astroglial glutamate transporter, GLT-1. We and others have shown that this transporter undergoes endocytosis and degradation in response to activation of protein kinase C (PKC),...

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Identifiers

PMID: 18805448
DOI: 10.1016/j.neuint.2008.07.010
PMCID: PMC2629405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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