Article

SUMO2 Protects Against Tau-induced Synaptic and Cognitive Dysfunction

2022-11-13

Abstract excerpt

<h4>Summary</h4> Abnormal intracellular accumulation of Tau aggregates is a hallmark of Alzheimer’s disease (AD) and other Tauopathies, such as Frontotemporal dementia (FTD), which can be caused by mutations of Tau. Mutated and pathological Tau can undergo a range of post-translational modifications (PTMs) that might trigger or modulate disease pathology. Recent studies indicate that modification of wild type Tau...

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Literature Corpus work: 83b2e06b-4aac-5bfc-9db1-abb41d913621
DOI: 10.1101/2022.11.11.516192

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