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Article

Epigenetic regulation of neuron‐dependent induction of astroglial synaptic protein GLT1

11 Aug 2009

Abstract excerpt

Astroglial glutamate transporter EAAT2/GLT1 prevents glutamate-induced excitotoxicity in the central nervous system. Expression of EAAT2/GLT1 is dynamically regulated by neurons. The pathogenesis of amyotrophic lateral sclerosis (ALS) involves astroglial dysfunction, including dramatic loss of EAAT2/GLT1. DNA methylation of gene promoters represents one of the most important epigenetic mechanisms in regulating...

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PMID: 19672971
DOI: 10.1002/glia.20922

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