Article
Transition Mutations in the hTERT Promoter Are Unrelated to Potential i-motif Formation in the C-Rich Strand.
Biomolecules - 25 Aug 2023
Conrad James W, Sowers Mark L, Yap Dianne Y, Cherryhomes Ellie, Pettitt B Montgomery, Khanipov Kamil, Sowers Lawrence C
Abstract excerpt
Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients. Cytosine-to-thymine (C-to-T) transition mutations (C250T or C228T) in the hTERT promoter create binding sites for transcription factors, which enhance transcription. The G-rich strand of the hTERT promoter can form G-quadruplex structures, whereas the C-rich...
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