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Article

DNA structure-induced genomic instability in vivo.

Journal of the National Cancer Institute - 17 Dec 2008

Wang Guliang, Carbajal Steve, Vijg Jan, DiGiovanni John, Vasquez Karen M

Abstract excerpt

Noncanonical DNA structures are postulated to be responsible for some breakpoint hotspots that occur frequently in cancers. We developed a novel mouse model system using the naturally occurring H-DNA structure that deviate from the familiar right-handed helical B form found at the breakage hotspot in the human c-MYC promoter and a Z-DNA-forming CG repeat to test this idea directly. Large-scale chromosomal...

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Share to Chromosome Aberrations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Inversion

Share to DNA, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Instability

Share to Translocation, Genetic

Source

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Identifiers

PMID: 19066276
DOI: 10.1093/jnci/djn385
PMCID: PMC2639325

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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