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Article

Distinct DNA repair pathways cause genomic instability at alternative DNA structures.

Nature communications - 13 Jan 2020

McKinney Jennifer A, Wang Guliang, Mukherjee Anirban, Christensen Laura, Subramanian Sai H Sankara, Zhao Junhua, Vasquez Karen M

Abstract excerpt

Alternative DNA structure-forming sequences can stimulate mutagenesis and are enriched at mutation hotspots in human cancer genomes, implicating them in disease etiology. However, the mechanisms involved are not well characterized. Here, we discover that Z-DNA is mutagenic in yeast as well as human cells, and that the nucleotide excision repair complex, Rad10-Rad1(ERCC1-XPF), and the mismatch repair complex,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31932649
DOI: 10.1038/s41467-019-13878-9
PMCID: PMC6957503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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