Article
Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes.
Cell reports - 30 Jan 2018
Zhao Junhua, Wang Guliang, Del Mundo Imee M, McKinney Jennifer A, Lu Xiuli, Bacolla Albino, Boulware Stephen B, Zhang Changsheng, Zhang Haihua, Ren Pengyu, Freudenreich Catherine H, Vasquez Karen M
Abstract excerpt
Sequences with the capacity to adopt alternative DNA structures have been implicated in cancer etiology; however, the mechanisms are unclear. For example, H-DNA-forming sequences within oncogenes have been shown to stimulate genetic instability in mammals. Here, we report that H-DNA-forming sequences are enriched at translocation breakpoints in human cancer genomes, further implicating them in cancer etiology....
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