Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency.

Cell reports - 21 Mar 2017

Hoffmeyer Katrin, Junghans Dirk, Kanzler Benoit, Kemler Rolf

Abstract excerpt

Wnt/β-catenin signaling is required for embryonic stem cell (ESC) pluripotency by inducing mesodermal differentiation and inhibiting neuronal differentiation; however, how β-catenin counter-regulates these differentiation pathways is unknown. Here, we show that lysine 49 (K49) of β-catenin is trimethylated (β-catMe3) by Ezh2 or acetylated (β-catAc) by Cbp. Significantly, β-catMe3 acts as a transcriptional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to beta Catenin
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer of Zeste Homolog 2 Protein

Share to Methylation

Share to Pluripotent Stem Cells

Share to Polycomb Repressive Complex 2

Share to Rats, Inbred Lew

Source

Identifiers

PMID: 28329675
DOI: 10.1016/j.celrep.2017.02.076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency.PMID 28329675Read ↗

SOX transcription factors direct TCF-independent WNT/beta-catenin transcriptionSemantic proximity Read ↗

β-catenin deacetylation is essential for WNT-induced proliferation of breast cancer cells.Semantic proximity Read ↗

TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation.Semantic proximity Read ↗

Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survivalSemantic proximity Read ↗

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.Semantic proximity Read ↗

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.Semantic proximity Read ↗

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions.Semantic proximity Read ↗

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction.Semantic proximity Read ↗

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.Semantic proximity Read ↗

Enhancer pioneering activity of Wnt/β-catenin signalingSemantic proximity Read ↗

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.Semantic proximity Read ↗

Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/β-catenin, Activin/Nodal and BMP signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.