Article

Epigenetic inactivation of oncogenic brachyury (TBXT) by H3K27 histone demethylase controls chordoma cell survival

2018-10-01

Abstract excerpt

The expression of the transcription factor brachyury ( TBXT ) is normally restricted to embryonic development and its silencing after mesoderm development is epigenetically regulated. In chordoma, a rare tumour of notochordal differentiation, TBXT acts as a putative oncogene, and we hypothesised that its expression could be controlled through epigenetic inhibition. Screening of five chordoma cell lines revealed...

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Literature Corpus work: e9f9156d-1afd-5b50-90d6-bc29a3a9d2f3
DOI: 10.1101/432005

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