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Article

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch Signaling

22 Mar 2017

Abstract excerpt

Rationale: Angiogenesis improves perfusion to the ischemic tissue after acute vascular obstruction. Angiogenesis in pathophysiological settings reactivates signaling pathways involved in developmental angiogenesis. We showed previously that AIBP (apolipoprotein A-I [apoA-I]–binding protein)–regulated cholesterol efflux in endothelial cells controls zebra fish embryonic angiogenesis. Objective: This study is to...

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PMID: 28325782
DOI: 10.1161/circresaha.116.309754

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