Article
Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73 to 76.
Neurobiology of aging - 1 Jun 2017
Cox Simon R, Ritchie Stuart J, Dickie David Alexander, Pattie Alison, Royle Natalie A, Corley Janie, Aribisala Benjamin S, Harris Sarah E, Valdés Hernández Maria, Gow Alan J, Muñoz Maniega Susana, Starr John M, Bastin Mark E, Wardlaw Joanna M, Deary Ian J
Abstract excerpt
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective...
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