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Article

Cerebrovascular risk factors and preclinical memory decline in healthy APOE ε4 homozygotes.

Neurology - 22 Mar 2011

Caselli R J, Dueck A C, Locke D E C, Sabbagh M N, Ahern G L, Rapcsak S Z, Baxter L C, Yaari R, Woodruff B K, Hoffman-Snyder C, Rademakers R, Findley S, Reiman E M

Abstract excerpt

OBJECTIVE: To characterize the effects of cerebrovascular (CV) risk factors on preclinical memory decline in cognitively normal individuals at 3 levels of genetic risk for Alzheimer disease (AD) based on APOE genotype. METHODS: We performed longitudinal neuropsychological testing on an APOE ε4 enriched cohort, ages 21-97. The long-term memory (LTM) score of the Auditory Verbal Learning Test (AVLT) was the primary...

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Identifiers

PMID: 21325652
DOI: 10.1212/WNL.0b013e318211c3ae
PMCID: PMC3068011

Genes

APOE

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