Article
White Matter Lesion Progression: Genome-Wide Search for Genetic Influences.
Stroke - 1 Nov 2015
Hofer Edith, Cavalieri Margherita, Bis Joshua C, DeCarli Charles, Fornage Myriam, Sigurdsson Sigurdur, Srikanth Velandai, Trompet Stella, Verhaaren Benjamin F J, Wolf Christiane, Yang Qiong, Adams Hieab H H, Amouyel Philippe, Beiser Alexa, Buckley Brendan M, Callisaya Michele, Chauhan Ganesh, de Craen Anton J M, Dufouil Carole, van Duijn Cornelia M, Ford Ian, Freudenberger Paul, Gottesman Rebecca F, Gudnason Vilmundur, Heiss Gerardo, Hofman Albert, Lumley Thomas, Martinez Oliver, Mazoyer Bernard, Moran Chris, Niessen Wiro J, Phan Thanh, Psaty Bruce M, Satizabal Claudia L, Sattar Naveed, Schilling Sabrina, Shibata Dean K, Slagboom P Eline, Smith Albert, Stott David J, Taylor Kent D, Thomson Russell, Töglhofer Anna M, Tzourio Christophe, van Buchem Mark, Wang Jing, Westendorp Rudi G J, Windham B Gwen, Vernooij Meike W, Zijdenbos Alex, Beare Richard, Debette Stéphanie, Ikram M Arfan, Jukema J Wouter, Launer Lenore J, Longstreth W T, Mosley Thomas H, Seshadri Sudha, Schmidt Helena, Schmidt Reinhold
Abstract excerpt
BACKGROUND AND PURPOSE: White matter lesion (WML) progression on magnetic resonance imaging is related to cognitive decline and stroke, but its determinants besides baseline WML burden are largely unknown. Here, we estimated heritability of WML progression, and sought common genetic variants associated with WML progression in elderly participants from the Cohorts for Heart and Aging Research in Genomic...
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