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Article

APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis.

Neurobiology of aging - 1 May 2017

Sudre Carole H, Cardoso M Jorge, Frost Chris, Barnes Josephine, Barkhof Frederik, Fox Nick, Ourselin Sébastien

Abstract excerpt

To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer's disease (AD). A purpose-built longitudinal automatic method was used to segment WMH using constraints derived from an...

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Source

Identifiers

PMID: 28235680
DOI: 10.1016/j.neurobiolaging.2017.01.014

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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