Article
Differential effects of white matter hyperintensity on geriatric depressive symptoms according to APOE-ε4 status.
Journal of affective disorders - 1 Dec 2015
Chang Ki Jung, Hong Chang Hyung, Lee Kang Soo, Roh Hyun Woong, Choi Seong Hye, Kim Seong Yoon, Na Duk L, Seo Sang Won, Kim Do-Kwan, Kang Dae Ryong, Kim Jayoun, Lee Yunhwan, Kim Si Heon, Back Joung Hwan, Chung Young Ki, Lim Ki Young, Noh Jai Sung, Oh Byung Hoon, Son Sang Joon
Abstract excerpt
BACKGROUND: We aimed to examine differential effects of WMH on progression of depressive symptoms according to APOE ε4 status in the elderly. METHODS: We obtained data from elderly Korean subjects (n=707) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A linear mixed model stratified according to APOE genotype (APOE ε4 carrier vs. non-carrier) was constructed using GDS...
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