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Article

The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.

Neurobiology of aging - 1 Jul 2012

McCarthy Jeanette J, Saith Sunita, Linnertz Colton, Burke James R, Hulette Christine M, Welsh-Bohmer Kathleen A, Chiba-Falek Ornit

Abstract excerpt

SORL1 has been identified as a major contributor to late onset Alzheimer's disease (LOAD). We test whether genetic variability in the 5' of SORL1 gene modulates the risk to develop LOAD via regulation of SORL1-messenger ribonucleic acid (mRNA) expression and splicing. Two brain structures, differentially vulnerable to LOAD pathology, were examined in 144 brain samples from 92 neurologically normal individuals....

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Source

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Identifiers

PMID: 21185108
DOI: 10.1016/j.neurobiolaging.2010.10.004
PMCID: PMC3117021

Genes

SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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