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Article

Convergent and divergent effects of apolipoprotein E ε4 and ε2 alleles on amygdala functional networks in nondemented older adults.

Neurobiology of aging - 1 Jun 2017

Gong Liang, Shu Hao, He Cancan, Ye Qing, Bai Feng, Xie Chunming, Zhang Zhijun

Abstract excerpt

Traditionally, in the context of Alzheimer's disease, the apolipoprotein E ε2 (APOEε2) allele is a protective factor and the APOEε4 allele is a destructive factor. However, this inverse relationship has recently been challenged, and the neural mechanisms underlying the effects of APOE genotype on Alzheimer's disease remain unclear. A resting-state functional magnetic resonance imaging study was conducted to...

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Source

Identifiers

PMID: 28319835
DOI: 10.1016/j.neurobiolaging.2017.02.013

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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