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Article

APOE Genotype Effects on Intrinsic Brain Network Connectivity in Patients with Amnestic Mild Cognitive Impairment.

Scientific reports - 24 Mar 2017

Wang Zan, Dai Zhengjia, Shu Hao, Liao Xuhong, Yue Chunxian, Liu Duan, Guo Qihao, He Yong, Zhang Zhijun

Abstract excerpt

Whether and how the apolipoprotein E (APOE) ε4 genotype specifically modulates brain network connectivity in patients with amnestic mild cognitive impairment (aMCI) remain largely unknown. Here, we employed resting-state ('task-free') functional MRI and network centrality approaches to investigate local (degree centrality, DC) and global (eigenvector centrality, EC) functional integrity in the whole-brain...

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Identifiers

PMID: 28341847
DOI: 10.1038/s41598-017-00432-0
PMCID: PMC5428452

Genes

APOE

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