Article
Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 13 Mar 2015
Chen Yaojing, Chen Kewei, Zhang Junying, Li Xin, Shu Ni, Wang Jun, Zhang Zhanjun, Reiman Eric M
Abstract excerpt
As the Apolipoprotein E (APOE) ɛ4 allele is a major genetic risk factor for sporadic Alzheimer's disease (AD), which has been suggested as a disconnection syndrome manifested by the disruption of white matter (WM) integrity and functional connectivity (FC), elucidating the subtle brain structural and functional network changes in cognitively normal ɛ4 carriers is essential for identifying sensitive neuroimaging...
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