Article
Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery.
Genes & development - 15 Oct 2002
Moshkin Yuri M, Armstrong Jennifer A, Maeda Robert K, Tamkun John W, Verrijzer Peter, Kennison James A, Karch Francois
Abstract excerpt
De novo chromatin assembly into regularly spaced nucleosomal arrays is essential for eukaryotic genome maintenance and inheritance. The Anti-Silencing Function 1 protein (ASF1) has been shown to be a histone chaperone, participating in DNA-replication-coupled nucleosome assembly. We show that mutations in the Drosophila asf1 gene derepress silencing at heterochromatin and that the ASF1 protein has a cell...
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