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Article

Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons.

Scientific reports - 17 Mar 2017

Halder Debasish, Lee Chang-Hee, Hyun Ji Young, Chang Gyeong-Eon, Cheong Eunji, Shin Injae

Abstract excerpt

Sin3 is a transcriptional corepressor for REST silencing machinery that represses multiple neuronal genes in non-neuronal cells. However, functions of Sin3 (Sin3A and Sin3B) in suppression of neuronal phenotypes are not well characterized. Herein we show that Sin3A knockdown impedes the repressive activity of REST and enhances differentiation of pluripotent P19 cells into electrophysiologically active neurons...

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Source

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Identifiers

PMID: 28303954
DOI: 10.1038/srep44818
PMCID: PMC5356016

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of Sin3A activity promotes differentiation of pluripotent cells into functional neurons.PMID 28303954Read ↗

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