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Article

Overexpression of TBX3 in human induced pluripotent stem cells (hiPSCs) increases their differentiation into cardiac pacemaker-like cells

6 Aug 2020

Abstract excerpt

BACKGROUD: The TBX3(T-box 3)transcription factor is considered as an essential factor in sinoatrial node formation. While the effect of TBX3 in the differentiation of sinoatrial node cells from embryonic stem cells(ESCs) has been recognized, its role in human induced pluripotent stem cell derived cardiomyocytes(hiPSCMs) has not been addressed. Therefore, the purpose of the present study was to investigate whether...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 32771895
DOI: 10.1016/j.biopha.2020.110612

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