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Article

The mammalian Sin3 proteins are required for muscle development and sarcomere specification.

Molecular and cellular biology - 1 Dec 2010

van Oevelen Chris, Bowman Christopher, Pellegrino Jessica, Asp Patrik, Cheng Jemmie, Parisi Fabio, Micsinai Mariann, Kluger Yuval, Chu Alphonse, Blais Alexandre, David Gregory, Dynlacht Brian D

Abstract excerpt

The highly related mammalian Sin3A and Sin3B proteins provide a versatile platform for chromatin-modifying activities. Sin3-containing complexes play a role in gene repression through deacetylation of nucleosomes. Here, we explore a role for Sin3 in myogenesis by examining the phenotypes resulting from acute somatic deletion of both isoforms in vivo and from primary myotubes in vitro. Myotubes ablated for Sin3A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20956564
DOI: 10.1128/MCB.00975-10
PMCID: PMC3004272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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